Title : IL-1 receptor antagonist improves morphine and buprenorphine efficacy in a rat neuropathic pain model.

Pub. Date : 2015 Oct 5

PMID : 26043968






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1 In summary, restoration of the analgesic activity of morphine and buprenorphine by blockade of IL-1 signaling suggests that increased IL-1beta responses may account for the decreased analgesic efficacy of opioids observed in the treatment of neuropathy. Buprenorphine interleukin 1 beta Rattus norvegicus