Title : Inhibition of mTORC2 Induces Cell-Cycle Arrest and Enhances the Cytotoxicity of Doxorubicin by Suppressing MDR1 Expression in HCC Cells.

Pub. Date : 2015 Aug

PMID : 26026051






3 Functional Relationships(s)
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1 In this study, we examined the interaction between the dual mTORC1/2 inhibitor OSI-027 and doxorubicin in vitro and in vivo. OSI 027 CREB regulated transcription coactivator 1 Mus musculus
2 OSI-027 was found to reduce phosphorylation of both mTORC1 and mTORC2 substrates, including 4E-BP1, p70S6K, and AKT (Ser473), and inhibit HCC cell proliferation. OSI 027 CREB regulated transcription coactivator 1 Mus musculus
3 Our findings provide a rationale for dual mTORC1/mTORC2 inhibitors, such as OSI-027, as monotherapy or in combination with cytotoxic agents to treat HCC. OSI 027 CREB regulated transcription coactivator 1 Mus musculus