Pub. Date : 2015 May 30
PMID : 26024660
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | ROS-p53-cyclophilin-D signaling mediates salinomycin-induced glioma cell necrosis. | salinomycin | tumor protein p53 | Homo sapiens |
| 2 | Salinomycin induced p53 translocation to mitochondria, where it formed a complex with cyclophilin-D (CyPD). | salinomycin | tumor protein p53 | Homo sapiens |
| 3 | Meanwhile, p53 stable knockdown alleviated salinomycin-induced necrosis in glioma cells. | salinomycin | tumor protein p53 | Homo sapiens |
| 4 | Reactive oxygen species (ROS) production was required for salinomycin-induced p53 mitochondrial translocation, mPTP opening and necrosis, and anti-oxidants n-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC) inhibited p53 translocation, mPTP opening and glioma cell death. | salinomycin | tumor protein p53 | Homo sapiens |
| 5 | Reactive oxygen species (ROS) production was required for salinomycin-induced p53 mitochondrial translocation, mPTP opening and necrosis, and anti-oxidants n-acetylcysteine (NAC) and pyrrolidine dithiocarbamate (PDTC) inhibited p53 translocation, mPTP opening and glioma cell death. | salinomycin | tumor protein p53 | Homo sapiens |