Pub. Date : 2015 May
PMID : 26018518
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to yield alpha-ketoglutarate (alpha-KG) with production of reduced nicotinamide adenine dinucleotide (NADH). | NAD | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 2 | BACKGROUND: Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to yield alpha-ketoglutarate (alpha-KG) with production of reduced nicotinamide adenine dinucleotide (NADH). | NAD | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 3 | BACKGROUND: Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to yield alpha-ketoglutarate (alpha-KG) with production of reduced nicotinamide adenine dinucleotide (NADH). | NAD | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 4 | BACKGROUND: Isocitrate dehydrogenase (IDH) catalyzes the oxidative decarboxylation of isocitrate to yield alpha-ketoglutarate (alpha-KG) with production of reduced nicotinamide adenine dinucleotide (NADH). | NAD | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |
| 5 | Dysfunctional IDH leads to reduced production of alpha-KG and NADH and increased production of 2-hydroxyglutarate, an oncometabolite. | NAD | isocitrate dehydrogenase (NADP(+)) 1 | Homo sapiens |