Title : [Triptolide induces apoptosis of human acute T lymphocytic leukemia Jurkat cells via inhibiting transcription of human endogenous retrovirus HERV-K Np9 gene].

Pub. Date : 2015 May

PMID : 26018266






2 Functional Relationships(s)
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1 Western blotting results displayed that triptolide inhibited transcription levels of Np9 mRNA with a concomitant decrease of its downstream signaling molecules c-myc, beta-catenin, ERK, AKT and Notch1 at protein levels. triptolide MYC proto-oncogene, bHLH transcription factor Homo sapiens
2 CONCLUSION: Inhibition of HERV-K Np9 mRNA and its downstream signaling molecules c-myc, beta-catenin, ERK, Akt and Notch1 protein might be one of important molecular?mechanisms by which triptolide induces apoptosis of human acute T lymphocytic leukemia Jurkat cells. triptolide MYC proto-oncogene, bHLH transcription factor Homo sapiens