Pub. Date : 2015 May
PMID : 26018266
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Western blotting results displayed that triptolide inhibited transcription levels of Np9 mRNA with a concomitant decrease of its downstream signaling molecules c-myc, beta-catenin, ERK, AKT and Notch1 at protein levels. | triptolide | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |
2 | CONCLUSION: Inhibition of HERV-K Np9 mRNA and its downstream signaling molecules c-myc, beta-catenin, ERK, Akt and Notch1 protein might be one of important molecular?mechanisms by which triptolide induces apoptosis of human acute T lymphocytic leukemia Jurkat cells. | triptolide | MYC proto-oncogene, bHLH transcription factor | Homo sapiens |