Title : H-7, a protein kinase C inhibitor, inhibits phorbol ester-caused ornithine decarboxylase induction but fails to inhibit phorbol ester-caused suppression of epidermal growth factor binding in primary cultured mouse epidermal cells.

Pub. Date : 1989 Dec

PMID : 2601687






6 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC) and suppressed 125I-epidermal growth factor (EGF) binding in primary cultured mouse epidermal cells. Tetradecanoylphorbol Acetate epidermal growth factor Mus musculus
2 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC) and suppressed 125I-epidermal growth factor (EGF) binding in primary cultured mouse epidermal cells. Tetradecanoylphorbol Acetate epidermal growth factor Mus musculus
3 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC) and suppressed 125I-epidermal growth factor (EGF) binding in primary cultured mouse epidermal cells. Tetradecanoylphorbol Acetate epidermal growth factor Mus musculus
4 12-O-tetradecanoylphorbol-13-acetate (TPA) induced ornithine decarboxylase (ODC) and suppressed 125I-epidermal growth factor (EGF) binding in primary cultured mouse epidermal cells. Tetradecanoylphorbol Acetate epidermal growth factor Mus musculus
5 TPA (30 nM)-caused ODC induction was almost completely blocked by 30 microM H-7 [1-(5-isoquinolinylsulfonyl)-2-methylpiperazine], a well known protein kinase C inhibitor, but the same concentration of H-7 failed to restore the 125I-EGF binding suppressed by TPA (10 nM). Tetradecanoylphorbol Acetate epidermal growth factor Mus musculus
6 On the other hand, sphingosine, another protein kinase C inhibitor, blocked not only TPA-caused ODC induction but also TPA-caused suppression of 125I-EGF binding. Tetradecanoylphorbol Acetate epidermal growth factor Mus musculus