Title : Mitochondrial function and regulation of macrophage sterol metabolism and inflammatory responses.

Pub. Date : 2015 May 26

PMID : 26015858






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 There is clear evidence that targeting either of these proteins enhances removal of cholesterol via LXRalpha-dependent induction of ATP binding cassette transporters (ABCA1, ABCG1) and limits the production of inflammatory cytokines; interventions which influence mitochondrial structure and bioenergetics also impact on removal of cholesterol from macrophages. Cholesterol nuclear receptor subfamily 1 group H member 3 Homo sapiens
2 There is clear evidence that targeting either of these proteins enhances removal of cholesterol via LXRalpha-dependent induction of ATP binding cassette transporters (ABCA1, ABCG1) and limits the production of inflammatory cytokines; interventions which influence mitochondrial structure and bioenergetics also impact on removal of cholesterol from macrophages. Cholesterol nuclear receptor subfamily 1 group H member 3 Homo sapiens