Title : PI3K target based novel cyano derivative of betulinic acid induces its signalling inhibition by down-regulation of pGSK3β and cyclin D1 and potentially checks cancer cell proliferation.

Pub. Date : 2016 May

PMID : 26013878






1 Functional Relationships(s)
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1 Thus, our results elucidated that CBA or other BA based small molecules inhibit PI3K/AKT pathway with induction of subsequent cancer cell death which may be useful therapeutic strategy against leukemias and possibly other cancers. betulinic acid AKT serine/threonine kinase 1 Homo sapiens