Pub. Date : 2015 Sep
PMID : 26004316
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Perfluorooctane sulfonate mediates microglial activation and secretion of TNF-alpha through Ca2+-dependent PKC-NF-kB signaling. | perfluorooctane sulfonic acid | tumor necrosis factor | Homo sapiens |
| 2 | In our research, we found that HAPI microglia secreted tumor necrosis factor-alpha (TNF-alpha) after PFOS exposure in time-dependent and dose-dependent way. | perfluorooctane sulfonic acid | tumor necrosis factor | Homo sapiens |
| 3 | In our research, we found that HAPI microglia secreted tumor necrosis factor-alpha (TNF-alpha) after PFOS exposure in time-dependent and dose-dependent way. | perfluorooctane sulfonic acid | tumor necrosis factor | Homo sapiens |
| 4 | It was noteworthy here the secretion of TNF-alpha mediated by PFOS was blocked by Ca(2+) inhibitor and protein kinase C (PKC) inhibitor. | perfluorooctane sulfonic acid | tumor necrosis factor | Homo sapiens |
| 5 | Finally, through treating SH-SY5Y cells with PFOS-treated microglial conditioned medium, we demonstrated that TNF-alpha mediated neuronal apoptosis. | perfluorooctane sulfonic acid | tumor necrosis factor | Homo sapiens |
| 6 | To sum up, our research had shown, for the first time, that the distinct TNF-alpha secretion brought by PFOS in HAPI microglia, was achieved through the Ca(2+)-dependent PKC-NF-kB signaling, subsequently participating in neuronal loss. | perfluorooctane sulfonic acid | tumor necrosis factor | Homo sapiens |