Title : [Methionine metabolism regulates maintenance and differentiation of human ES/iPS cells].

Pub. Date : 2015 May

PMID : 25985628






1 Functional Relationships(s)
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1 Met deprivation results in a rapid decrease in intracellular S-adenosyl-methionine (SAM), triggering the activation of p53 signaling, reducing pluripotent marker gene NANOG expression, and poising human ES/iPS cells for differentiation, follow by potentiated differentiation into all three germ layers. S-Adenosylmethionine tumor protein p53 Homo sapiens