Pub. Date : 2015 Oct
PMID : 25980448
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | A population-based study of the drug interaction between clopidogrel and angiotensin converting enzyme inhibitors. | Clopidogrel | angiotensin I converting enzyme | Homo sapiens |
| 2 | Clopidogrel inhibits carboxylesterase 1 (CES1), the enzyme responsible for converting prodrug ACE inhibitors (such as ramipril and perindopril) to their active metabolites. | Clopidogrel | angiotensin I converting enzyme | Homo sapiens |
| 3 | CONCLUSIONS: Following myocardial infarction, use of clopidogrel with ACE inhibitors activated by CES1 is not associated with an increased risk of adverse cardiovascular outcomes relative to lisinopril. | Clopidogrel | angiotensin I converting enzyme | Homo sapiens |
| 4 | These findings suggest that the recently described drug interaction between clopidogrel and prodrug ACE inhibitors is of little clinical relevance. | Clopidogrel | angiotensin I converting enzyme | Homo sapiens |