Pub. Date : 2015
PMID : 25973024
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Inositol hexaphosphate suppresses growth and induces apoptosis in HT-29 colorectal cancer cells in culture: PI3K/Akt pathway as a potential target. | Phytic Acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Therefore, this study was conducted to investigate the activity of IP6 against human colorectal cancer cells (HT-29) and to determine whether the IP6 regulates apoptosis in HT-29 cells by inhibiting the PI3K/Akt signaling pathway. | Phytic Acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | The mRNA and protein expression of PI3K and Akt decreased in the groups treated with IP6, and IP6 inhibited the phosphorylation of Akt (pAkt), whereas increased the expression of its downstream effector, caspase-9. | Phytic Acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | The mRNA and protein expression of PI3K and Akt decreased in the groups treated with IP6, and IP6 inhibited the phosphorylation of Akt (pAkt), whereas increased the expression of its downstream effector, caspase-9. | Phytic Acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | The mRNA and protein expression of PI3K and Akt decreased in the groups treated with IP6, and IP6 inhibited the phosphorylation of Akt (pAkt), whereas increased the expression of its downstream effector, caspase-9. | Phytic Acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 6 | The mRNA and protein expression of PI3K and Akt decreased in the groups treated with IP6, and IP6 inhibited the phosphorylation of Akt (pAkt), whereas increased the expression of its downstream effector, caspase-9. | Phytic Acid | AKT serine/threonine kinase 1 | Homo sapiens |
| 7 | CONCLUSION: Our results suggested that by targeting PI3K/Akt pathway, IP6 suppresses cell survival and proliferation, but induces death in HT-29 cells. | Phytic Acid | AKT serine/threonine kinase 1 | Homo sapiens |