Title : The role of NF-κB in PARP-inhibitor-mediated sensitization and detoxification of arsenic trioxide in hepatocellular carcinoma cells.

Pub. Date : 2015 Jun

PMID : 25972196






2 Functional Relationships(s)
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1 Furthermore, the attenuation of ATO-induced ROS and the resulting oxidative DNA damage by N-acetyl-L-cysteine (NAC), a potent antioxidant, significantly reduced the activation of PARP-1 and NF-kappaB in ATO-treated cells. Arsenic Trioxide X-linked Kx blood group Homo sapiens
2 Furthermore, the attenuation of ATO-induced ROS and the resulting oxidative DNA damage by N-acetyl-L-cysteine (NAC), a potent antioxidant, significantly reduced the activation of PARP-1 and NF-kappaB in ATO-treated cells. Arsenic Trioxide X-linked Kx blood group Homo sapiens