Pub. Date : 2015 Sep
PMID : 25971793
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
1 | Sesquiterpene lactone parthenolide attenuates production of inflammatory mediators by suppressing the Toll-like receptor-4-mediated activation of the Akt, mTOR, and NF-kappaB pathways. | parthenolide | toll like receptor 4 | Homo sapiens |
2 | Using human keratinocytes, we investigated the effect of parthenolide on the inflammatory mediator production in relation to the Toll-like receptor-4-mediated-Akt/mTOR and NF-kappaB pathways, which regulate the transcription genes involved in immune and inflammatory responses. | parthenolide | toll like receptor 4 | Homo sapiens |
3 | The results show that parthenolide appears to attenuate the lipopolysaccharide-stimulated production of inflammatory mediators in keratinocytes by suppressing the Toll-like receptor-4-mediated activation of the Akt, mTOR, and NF-kappaB pathways. | parthenolide | toll like receptor 4 | Homo sapiens |