Pub. Date : 2015 Aug 15
PMID : 25968119
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Upon Lys treatment, Gcdh-/- astrocytes synthetized and released GA and 3-hydroxyglutaric acid (3HGA). | glutaric acid | glutaryl-Coenzyme A dehydrogenase | Mus musculus |
| 2 | In contrast, Lys or GA direct exposure on Gcdh-/- or WT striatal neurons cultured in the absence of astrocytes was not toxic, indicating that neuronal death is mediated by astrocytes. | glutaric acid | glutaryl-Coenzyme A dehydrogenase | Mus musculus |
| 3 | In summary, GCDH-defective astrocytes actively contribute to produce and accumulate GA and 3HGA when Lys catabolism is stressed. | glutaric acid | glutaryl-Coenzyme A dehydrogenase | Mus musculus |