Pub. Date : 2015 Jun
PMID : 25964092
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Activation of M3 muscarinic receptor by acetylcholine promotes non-small cell lung cancer cell proliferation and invasion via EGFR/PI3K/AKT pathway. | Acetylcholine | cholinergic receptor muscarinic 3 | Homo sapiens |
| 2 | Activation of M3R by ACh participates in the proliferation, differentiation, transformation, and carcinogenesis of cancer. | Acetylcholine | cholinergic receptor muscarinic 3 | Homo sapiens |
| 3 | After silencing of M3R, the biological functions of ACh in NSCLC cells were greatly attenuated. | Acetylcholine | cholinergic receptor muscarinic 3 | Homo sapiens |
| 4 | Furthermore, ACh stimulation increased the production of IL-8 and time-dependently induced the activation of EGFR, PI3K, and AKT through M3R. | Acetylcholine | cholinergic receptor muscarinic 3 | Homo sapiens |
| 5 | Taken together, these findings indicate that activation of M3R by ACh enhances the proliferation, invasion, and migration of NSCLC cells. | Acetylcholine | cholinergic receptor muscarinic 3 | Homo sapiens |
| 6 | ACh-induced activation of EGFR/PI3K/AKT pathway and subsequent IL-8 upregulation may be one of the important mechanisms of M3R function. | Acetylcholine | cholinergic receptor muscarinic 3 | Homo sapiens |