Title : Sequential transformation of 4-androstenedione into dihydrotestosterone in prostate carcinoma (DU-145) cells indicates that 4-androstenedione and not testosterone is the substrate of 5α-reductase.

Pub. Date : 2010 Jan 1

PMID : 25961972






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 The present data clearly indicate that the biosynthesis of dihydrotestosterone in DU-145 cells does not require testosterone as intermediate, and the step catalyzed by 5alpha-reductase precedes the step catalyzed by 17beta-hydroxysteroid dehydrogenase. Testosterone hydroxysteroid 17-beta dehydrogenase 7 Homo sapiens