Pub. Date : 2015 Jun
PMID : 25959621
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Instant coffee extract with high chlorogenic acids content inhibits hepatic G-6-Pase in vitro, but does not reduce the glycaemia. | Chlorogenic Acid | glucose-6-phosphatase catalytic subunit 1 | Homo sapiens |
| 2 | Instant coffee extract with high chlorogenic acids content (37.8%) inhibited (p < 0.05) the G-6-Pase activity of the hepatocyte microsomal fraction in a dose-dependent way (up to 53), but IV administration of this extract did not change the glycaemia (p > 0.05). | Chlorogenic Acid | glucose-6-phosphatase catalytic subunit 1 | Homo sapiens |
| 3 | It was concluded that instant coffee extract with high content of chlorogenic acids inhibited hepatic G-6-Pase in vitro, but failed to reduce the glycaemia probably because the coffee chlorogenic acids did not reach enough levels within the hepatocytes to inhibit the G-6-Pase and reduce the liver glucose output. | Chlorogenic Acid | glucose-6-phosphatase catalytic subunit 1 | Homo sapiens |