Title : Phase II trial of gemcitabine and tanespimycin (17AAG) in metastatic pancreatic cancer: a Mayo Clinic Phase II Consortium study.

Pub. Date : 2015 Aug

PMID : 25952464






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Gemcitabine, which has modest activity in pancreas cancer, activates Chk1, a client protein of HSP90. gemcitabine checkpoint kinase 1 Homo sapiens
2 This phase II trial was designed to determine whether 17AAG could enhance the clinical activity of gemcitabine through degradation of Chk1 in patients with stage IV pancreatic cancer. gemcitabine checkpoint kinase 1 Homo sapiens