Title : Hypoxanthine deregulates genes involved in early neuronal development. Implications in Lesch-Nyhan disease pathogenesis.

Pub. Date : 2015 Nov

PMID : 25940910






1 Functional Relationships(s)
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1 We report that hypoxanthine excess deregulate WNT4, from Wnt/beta-catenin pathway, and engrailed homeobox 1 gene and increased TH and dopamine DRD1, adenosine ADORA2A and serotonin HTR7 receptors, whose over expression characterize early neuro-developmental processes. Hypoxanthine adenosine A2a receptor Homo sapiens