Title : Acyl-CoA-binding domain containing 3 modulates NAD+ metabolism through activating poly(ADP-ribose) polymerase 1.

Pub. Date : 2015 Jul 15

PMID : 25940138






2 Functional Relationships(s)
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1 In the present study, we showed that overexpressed acyl-CoA-binding domain containing 3 (ACBD3), a Golgi-bound protein, significantly reduced cellular NAD(+) content via enhancing PARP1"s polymerase activity and enhancing auto-modification of the enzyme in a DNA damage-independent manner. NAD acyl-CoA binding domain containing 3 Homo sapiens
2 Taken together, these findings suggest that ACBD3 has prominent impacts on cellular NAD(+) metabolism via regulating PARP1 activation-dependent auto-modification and thus cell metabolism and function. NAD acyl-CoA binding domain containing 3 Homo sapiens