Pub. Date : 2015 Jun
PMID : 25933953
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | In the present study we used male rats to verify the hypothesis that the binding pattern of 5-HT2A and 5-HT2C receptors in the brain is altered by chronic nicotine treatment in different environments. | Nicotine | 5-hydroxytryptamine receptor 2A | Rattus norvegicus |
| 2 | RESULTS: Repeated treatment with nicotine in home cages evoked significant increases in [(3)H]ketanserin binding to 5-HT2A receptors in the prefrontal cortex, striatal subregions and ventral tegmental area as well as reductions in [(3)H]mesulergine binding to 5-HT2C receptors in subregions of the prefrontal cortex. | Nicotine | 5-hydroxytryptamine receptor 2A | Rattus norvegicus |
| 3 | In contrast, nicotine paired with environmental context produced robust increases in 5-HT2A receptor labeling in the infralimbic cortex and decreased [(3)H]ketanserin binding in striatal subregions and ventral tegmental area; 5-HT2C receptor labeling in the prefrontal cortex fell. | Nicotine | 5-hydroxytryptamine receptor 2A | Rattus norvegicus |
| 4 | CONCLUSIONS: The present data indicate that chronic nicotine administration in home cages induces bi-directional neuroplastic changes within 5-HT2A and 5-HT2C receptors in the prefrontal cortex. | Nicotine | 5-hydroxytryptamine receptor 2A | Rattus norvegicus |
| 5 | Pairing the nicotine with environmental context potentiates the neuroplastic response in the latter region and evokes opposite changes in 5-HT2A receptor binding in striatal and tegmental regions compared with nicotine administered in the absence of the context, indicating a modulatory role of environmental context in the expression of nicotine-induced sensitization. | Nicotine | 5-hydroxytryptamine receptor 2A | Rattus norvegicus |