Pub. Date : 2015 May 1
PMID : 25929655
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | RESULTS: Compared with CLP group, dexmedetomidine significantly decreased not only the production of TNF-alpha and IL-6 both in plasma and BALF, but also inhibited the expression of TLR4 and MyD88 in mRNA level and the activation of ERK1/2 and NF-kappaB in the lung tissues of CLP-induced septic rats. | Dexmedetomidine | toll-like receptor 4 | Rattus norvegicus |
| 2 | These effects of dexmedetomidine rely on TLR4/MyD88/MAPK/ NF-kappaB signaling pathway and are independent of alpha2-adrenoceptor. | Dexmedetomidine | toll-like receptor 4 | Rattus norvegicus |