Title : The GLP-1 Receptor Agonist Exendin-4 and Diazepam Differentially Regulate GABAA Receptor-Mediated Tonic Currents in Rat Hippocampal CA3 Pyramidal Neurons.

Pub. Date : 2015

PMID : 25927918






1 Functional Relationships(s)
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1 In whole-cell recordings in rat brain slices, diazepam (1 muM), an allosteric positive modulator of GABAA receptors, alone enhanced the spontaneous inhibitory postsynaptic current (sIPSC) amplitude and frequency by a factor of 1.3 and 1.6, respectively, and doubled the tonic GABAA current normally recorded in the CA3 pyramidal cells. Diazepam carbonic anhydrase 3 Rattus norvegicus