Title : Intestinal epithelium-specific knockout of the cytochrome P450 reductase gene exacerbates dextran sulfate sodium-induced colitis.

Pub. Date : 2015 Jul

PMID : 25926522






1 Functional Relationships(s)
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1 DSS treatment (2.5% in drinking water for 6 days) caused more severe colon inflammation, as evidenced by the presence of higher levels of myeloperoxidase and proinflammatory cytokines [tumor necrosis factor-alpha, interleukin (IL)-6, and IL-1beta], and greater weight loss, colonic tissue damage, and colon shortening, in IE-Cpr-null mice than in WT mice. Dextran Sulfate interleukin 1 beta Mus musculus