Pub. Date : 2016 Jan
PMID : 25916979
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study attempted to investigate the value of ALDH1 as a predictive marker of chemosensitivity and its prognostic value in cervical cancer patients treated with NAC. | nac | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 2 | METHODS: Immunohistochemistry was used to evaluate ALDH1 expression in matched pre- and post-NAC tumor samples from 52 patients with cervical cancer. | nac | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 3 | RESULTS: Fourteen patients (26.9 %) had ALDH1-positive tumors pre-NAC, and ALDH1 expression pre-NAC was significantly associated with a low clinical chemotherapy response rate and clinical non-response. | nac | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 4 | Multivariate analysis revealed that ALDH1 expression post-NAC was an independent prognostic factor for OS (hazard ratio 3.513; p = 0.033). | nac | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 5 | Moreover, we observed that ALDH1 expression was increased after NAC in 18 patients (36.7 %). | nac | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 6 | Increased levels of ALDH1 expression after NAC predicted poor DFS and OS (p = 0.013 and p = 0.08, respectively). | nac | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 7 | CONCLUSIONS: Our findings suggest that ALDH1 expression pre-NAC may be a predictive marker for response to NAC, and ALDH1 expression post-NAC could be a prognostic marker for cervical cancer. | nac | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 8 | CONCLUSIONS: Our findings suggest that ALDH1 expression pre-NAC may be a predictive marker for response to NAC, and ALDH1 expression post-NAC could be a prognostic marker for cervical cancer. | nac | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |
| 9 | CONCLUSIONS: Our findings suggest that ALDH1 expression pre-NAC may be a predictive marker for response to NAC, and ALDH1 expression post-NAC could be a prognostic marker for cervical cancer. | nac | aldehyde dehydrogenase 1 family member A1 | Homo sapiens |