Pub. Date : 2015 Aug
PMID : 25912790
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | The Parkinson-associated human P5B-ATPase ATP13A2 protects against the iron-induced cytotoxicity. | Iron | ATPase cation transporting 13A2 | Homo sapiens |
| 2 | Loss-of-function mutations in the ATP13A2 gene (PARK9, OMIM 610513) underlay a form of Parkinson"s disease (PD) known as the Kufor-Rakeb syndrome (KRS), which belongs to the group of syndromes of neurodegeneration with brain iron accumulation (NBIA). | Iron | ATPase cation transporting 13A2 | Homo sapiens |
| 3 | Loss-of-function mutations in the ATP13A2 gene (PARK9, OMIM 610513) underlay a form of Parkinson"s disease (PD) known as the Kufor-Rakeb syndrome (KRS), which belongs to the group of syndromes of neurodegeneration with brain iron accumulation (NBIA). | Iron | ATPase cation transporting 13A2 | Homo sapiens |
| 4 | Moreover, the iron content in ATP13A2 cells was lower than control cells stably expressing an inactive mutant of ATP13A2. | Iron | ATPase cation transporting 13A2 | Homo sapiens |
| 5 | Moreover, the iron content in ATP13A2 cells was lower than control cells stably expressing an inactive mutant of ATP13A2. | Iron | ATPase cation transporting 13A2 | Homo sapiens |
| 6 | ATP13A2 cells exhibited a reduced iron-induced lysosome membrane permeabilization (LMP). | Iron | ATPase cation transporting 13A2 | Homo sapiens |
| 7 | These results suggest that ATP13A2 overexpression improves the lysosome membrane integrity and protects against the iron-induced cell damage. | Iron | ATPase cation transporting 13A2 | Homo sapiens |