Title : Calpain-Mediated Degradation of Drebrin by Excitotoxicity In vitro and In vivo.

Pub. Date : 2015

PMID : 25905636






3 Functional Relationships(s)
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Protein Name
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1 Here, we show that drebrin is a novel target of calpain-mediated proteolysis under excitotoxic conditions induced by the overactivation of NMDARs. nmdars drebrin 1 Homo sapiens
2 Drebrin regulates the synaptic clustering of NMDARs; therefore, degradation of drebrin under excitotoxic conditions may modulate NMDAR-mediated signal transductions, including pro-survival signaling. nmdars drebrin 1 Homo sapiens
3 Drebrin regulates the synaptic clustering of NMDARs; therefore, degradation of drebrin under excitotoxic conditions may modulate NMDAR-mediated signal transductions, including pro-survival signaling. nmdars drebrin 1 Homo sapiens