Pub. Date : 2015 Jul
PMID : 25904761
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Bupropion"s metabolism and the formation of hydroxybupropion in the liver by cytochrome P450 2B6 (CYP2B6) has been extensively studied; however, the metabolism and formation of erythro/threohydrobupropion in the liver and intestine by carbonyl reductases (CR) has not been well characterized. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | Bupropion"s metabolism and the formation of hydroxybupropion in the liver by cytochrome P450 2B6 (CYP2B6) has been extensively studied; however, the metabolism and formation of erythro/threohydrobupropion in the liver and intestine by carbonyl reductases (CR) has not been well characterized. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | The purpose of this investigation was to compare the relative contribution of the two metabolism pathways of bupropion (by CYP2B6 and CR) in the subcellular fractions of liver and intestine and to identify the CRs responsible for erythro/threohydrobupropion formation in the liver and the intestine. | Bupropion | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |