Title : Colchicine derivatives with potent anticancer activity and reduced P-glycoprotein induction liability.

Pub. Date : 2015 May 28

PMID : 25895604






4 Functional Relationships(s)
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1 Screening of the prepared derivatives for P-gp induction activity revealed that a number of derivatives possess remarkably lower P-gp-induction activity (>90% intracellular accumulation of rhodamine 123 in LS-180 cells) compared to the parent natural product colchicine (62% Rh123 accumulation in LS-180 cells). Rhodamine 123 phosphoglycolate phosphatase Homo sapiens
2 Screening of the prepared derivatives for P-gp induction activity revealed that a number of derivatives possess remarkably lower P-gp-induction activity (>90% intracellular accumulation of rhodamine 123 in LS-180 cells) compared to the parent natural product colchicine (62% Rh123 accumulation in LS-180 cells). Rhodamine 123 phosphoglycolate phosphatase Homo sapiens
3 Screening of the prepared derivatives for P-gp induction activity revealed that a number of derivatives possess remarkably lower P-gp-induction activity (>90% intracellular accumulation of rhodamine 123 in LS-180 cells) compared to the parent natural product colchicine (62% Rh123 accumulation in LS-180 cells). Rhodamine 123 phosphoglycolate phosphatase Homo sapiens
4 Screening of the prepared derivatives for P-gp induction activity revealed that a number of derivatives possess remarkably lower P-gp-induction activity (>90% intracellular accumulation of rhodamine 123 in LS-180 cells) compared to the parent natural product colchicine (62% Rh123 accumulation in LS-180 cells). Rhodamine 123 phosphoglycolate phosphatase Homo sapiens