Title : Sensitization of P2X3 receptors by cystathionine β-synthetase mediates persistent pain hypersensitivity in a rat model of lumbar disc herniation.

Pub. Date : 2015 Mar 20

PMID : 25885215






3 Functional Relationships(s)
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1 Interestingly, NP implantation significantly enhanced expression of the endogenous hydrogen sulfide producing enzyme, cystathionine-beta-synthetase (CBS). Hydrogen Sulfide cystathionine beta synthase Rattus norvegicus
2 Interestingly, NP implantation significantly enhanced expression of the endogenous hydrogen sulfide producing enzyme, cystathionine-beta-synthetase (CBS). Hydrogen Sulfide cystathionine beta synthase Rattus norvegicus
3 Our results suggest that sensitization of P2X3Rs, which is likely mediated by CBS-H2S signaling in primary sensory neurons, contributes to discogenic pain. Hydrogen Sulfide cystathionine beta synthase Rattus norvegicus