Title : [Kinetics of inhibition of aldehyde dehydrogenase isoenzymes of rat liver by fluorine-containing disulfides].

Pub. Date : 1989 Jul-Aug

PMID : 2588336






4 Functional Relationships(s)
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1 New disulphides synthesized on the basis of dithiocarboxylic acid derivatives and heterocyclic thiols containing the fluorine atoms were studied as applied to inhibit aldehyde dehydrogenase (ALDH) isozymes of the rat liver mitochondria. disulphides aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus
2 New disulphides synthesized on the basis of dithiocarboxylic acid derivatives and heterocyclic thiols containing the fluorine atoms were studied as applied to inhibit aldehyde dehydrogenase (ALDH) isozymes of the rat liver mitochondria. disulphides aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus
3 The ALDH inhibition by disulphides I, IV, VI-VIII was competitive both for the cofactor and for the substrate of the reaction. disulphides aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus
4 The protective effect of the NAD+ against ALDH I and II inactivation by disulfiram and disulphides I, IV, VI-VIII and X is shown. disulphides aldehyde dehydrogenase 3 family, member A1 Rattus norvegicus