Pub. Date : 2015 Feb 21
PMID : 25880226
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | pERK1/2 silencing sensitizes pancreatic cancer BXPC-3 cell to gemcitabine-induced apoptosis via regulating Bax and Bcl-2 expression. | gemcitabine | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 2 | It has also shown that Bcl-2 confers resistance and Bax sensitizes to gemcitabine-induced apoptosis in pancreatic cancer cells. | gemcitabine | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 3 | We therefore tested the hypothesis that pancreatic cancer cells are resistant to gemcitabine and this resistance is due to activation of ERK1/2 and subsequent upregulation of Bcl-2 and downregulation of Bax. | gemcitabine | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 4 | Combined treatment with PD98059 and Bax siRNA transfection could decrease gemcitabine-induced ERK1/2 and Bax activation, which subsequently resulted in decreased apoptosis. | gemcitabine | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 5 | Combined treatment with PD98059 and Bax siRNA transfection could decrease gemcitabine-induced ERK1/2 and Bax activation, which subsequently resulted in decreased apoptosis. | gemcitabine | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 6 | CONCLUSIONS: The upregulation of ERK1/2-dependent Bcl-2 and downregulation of ERK1/2-dependent Bax can protect human pancreatic cancer cells from gemcitabine-induced apoptosis. | gemcitabine | BCL2 associated X, apoptosis regulator | Homo sapiens |
| 7 | Targeting the ERK1/2-Bax/Bcl-2 pathway may in part lead to sensitization of pancreatic cancer to gemcitabine. | gemcitabine | BCL2 associated X, apoptosis regulator | Homo sapiens |