Pub. Date : 2015
PMID : 25878720
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | BACKGROUND: Polymorphisms in cytochrome P450 2B6 (CYP2B6) affect the steady state plasma concentration of nevirapine. | Nevirapine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 2 | BACKGROUND: Polymorphisms in cytochrome P450 2B6 (CYP2B6) affect the steady state plasma concentration of nevirapine. | Nevirapine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 3 | RESULTS: Women with CYP2B6 516TT genotype (n=9) had higher mean nevirapine plasma levels (14.33 mug/mL) compared to those with heterozygous 516GT (9.18 mug/mL; n=25) and wild- type 516GG (7.95 mug/mL; n=32) genotypes (P=0.01). | Nevirapine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 4 | Women heterozygous for the CYP2B6 983TC genotype (n=13) had higher mean nevirapine plasma levels (12.94 mug/mL), compared to women with the homozygous 983TT (8.35 mug/mL; n=53) genotype (P=0.007). | Nevirapine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 5 | CONCLUSIONS: CYP2B6 516G>T and CYP2B6 983T>C genotypes were strongly associated with plasma nevirapine concentration, which predicted immunologic response in women on nevirapine-based antiretroviral therapy. | Nevirapine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |
| 6 | CONCLUSIONS: CYP2B6 516G>T and CYP2B6 983T>C genotypes were strongly associated with plasma nevirapine concentration, which predicted immunologic response in women on nevirapine-based antiretroviral therapy. | Nevirapine | cytochrome P450 family 2 subfamily B member 6 | Homo sapiens |