Title : Intrahippocampal glutamine administration inhibits mTORC1 signaling and impairs long-term memory.

Pub. Date : 2015 May

PMID : 25878136






5 Functional Relationships(s)
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1 Intrahippocampal glutamine administration inhibits mTORC1 signaling and impairs long-term memory. Glutamine CREB regulated transcription coactivator 1 Mus musculus
2 In vitro studies using serum- and amino acid-starved cells have reported that glutamine addition can either stimulate or repress mTORC1 activity, depending on the particular experimental system that was used. Glutamine CREB regulated transcription coactivator 1 Mus musculus
3 We present experimental results indicating that intrahippocampal administration of glutamine to rats reduces mTORC1 activity. Glutamine CREB regulated transcription coactivator 1 Mus musculus
4 Taken together, these findings indicate that glutamine can decrease mTORC1 activity in the brain and may have implications for treatments of neurological diseases associated with high mTORC1 signaling. Glutamine CREB regulated transcription coactivator 1 Mus musculus
5 Taken together, these findings indicate that glutamine can decrease mTORC1 activity in the brain and may have implications for treatments of neurological diseases associated with high mTORC1 signaling. Glutamine CREB regulated transcription coactivator 1 Mus musculus