Title : Ligand Selectivity among the Dopamine and Serotonin Transporters Specified by the Forward Binding Reaction.

Pub. Date : 2015 Jul

PMID : 25873594






2 Functional Relationships(s)
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1 We exemplify our approach by measuring the kinetics of cocaine, methylphenidate, and desipramine binding to SERT and DAT. Desipramine solute carrier family 6 member 3 Homo sapiens
2 Our analysis revealed that the selectivity of methylphenidate and desipramine for DAT and SERT, respectively, can be accounted for by their rate of association and not by the residence time in their respective binding sites. Desipramine solute carrier family 6 member 3 Homo sapiens