Pub. Date : 2015 Jul
PMID : 25869642
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells. | Poly I-C | interferon beta 1, fibroblast | Mus musculus |
| 2 | Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells. | Poly I-C | interferon beta 1, fibroblast | Mus musculus |
| 3 | Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells. | Poly I-C | interferon beta 1, fibroblast | Mus musculus |
| 4 | Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells. | Poly I-C | interferon beta 1, fibroblast | Mus musculus |
| 5 | Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells. | Poly I-C | interferon beta 1, fibroblast | Mus musculus |
| 6 | Using IFN-beta reporter mice, we showed that direct administration of polyinosinic-polycytidylic acid (poly I:C), a potent inducer of IFN-beta, into the cerebrospinal fluid induced increased leukocyte numbers and transient upregulation of IFN-beta in CD45/CD11b-positive cells located in the meninges and choroid plexus, as well as enhanced IFN-beta expression by parenchymal microglial cells. | Poly I-C | interferon beta 1, fibroblast | Mus musculus |
| 7 | Intrathecal injection of poly I:C to mice showing first symptoms of EAE substantially increased the normal disease-associated expression of IFN-alpha, IFN-beta, interferon regulatory factor-7 and IL-10 in CNS, and disease worsening was prevented for as long as IFN-alpha/beta was expressed. | Poly I-C | interferon beta 1, fibroblast | Mus musculus |