Pub. Date : 2015 Jul
PMID : 25862630
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Enhanced sensitivity to sorafenib by inhibition of Akt1 expression in human renal cell carcinoma ACHN cells both in vitro and in vivo. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | To investigate whether antitumor activity of sorafenib, a potential molecular-targeted agent against RCC is enhanced by silencing Akt1 in a human RCC ACHN model. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | Changes in several phenotypes of ACHN/sh-Akt1 following treatment with sorafenib were compared with those of ACHN transfected with control vector alone (ACHN/C) both in vitro and in vivo. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | Furthermore, treatment with Akt1 inhibitor, A-674563 also resulted in the significantly enhanced sensitivity of parental ACHN to sorafenib. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |
| 5 | Treatment of ACHN/sh-Akt1 with sorafenib, but not that of ACHN/C, induced marked downregulation of antiapoptotic proteins, including Bcl-2, Bcl-xL, and c-Myc. | Sorafenib | AKT serine/threonine kinase 1 | Homo sapiens |