Title : Metformin inhibits the proliferation of human prostate cancer PC-3 cells via the downregulation of insulin-like growth factor 1 receptor.

Pub. Date : 2015 May 22

PMID : 25862373






2 Functional Relationships(s)
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1 IGF-1 activated both ERK1/2 and Akt, but these effects were attenuated by metformin treatment. Metformin insulin like growth factor 1 Homo sapiens
2 Our results suggest that metformin is a potent inhibitor of the IGF-1/IGF-1R system and may be beneficial in prostate cancer treatment. Metformin insulin like growth factor 1 Homo sapiens