Title : Polycyclic aromatic hydrocarbons reciprocally regulate IL-22 and IL-17 cytokines in peripheral blood mononuclear cells from both healthy and asthmatic subjects.

Pub. Date : 2015

PMID : 25860963






4 Functional Relationships(s)
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1 Polycyclic aromatic hydrocarbons reciprocally regulate IL-22 and IL-17 cytokines in peripheral blood mononuclear cells from both healthy and asthmatic subjects. Polycyclic Aromatic Hydrocarbons interleukin 17A Homo sapiens
2 We hypothesized that PAH might affect, through their effects on AhR, IL-17 and IL-22 production in allergic asthmatics. Polycyclic Aromatic Hydrocarbons interleukin 17A Homo sapiens
3 Diesel exhaust particle (DEP)-PAH and Benzo[a]Pyrene (B[a]P) stimulation further increased IL-22 but decreased IL-17A production in both groups. Polycyclic Aromatic Hydrocarbons interleukin 17A Homo sapiens
4 Among PBMCs, PAH-induced IL-22 expression originated principally from single IL-22- but not from IL-17- expressing CD4 T cells. Polycyclic Aromatic Hydrocarbons interleukin 17A Homo sapiens