Pub. Date : 2015 Jul 10
PMID : 25857968
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | We demonstrated that CPS-F not only inhibits platelet-derived growth factor BB (PDGF-BB)-induced intracellular reactive oxygen species (ROS) generation, and up-regulation of tumor necrosis factor-alpha (TNF-alpha), TNF-alpha receptor 1 (TNFR1), and monocyte chemotactic protein-1 (MCP-1), but also acts synergistically in combination with MAPK/ERK inhibitor U0126 and PI3K/Akt inhibitor LY294002. | Chlorpyrifos | tumor necrosis factor | Homo sapiens |
| 2 | We demonstrated that CPS-F not only inhibits platelet-derived growth factor BB (PDGF-BB)-induced intracellular reactive oxygen species (ROS) generation, and up-regulation of tumor necrosis factor-alpha (TNF-alpha), TNF-alpha receptor 1 (TNFR1), and monocyte chemotactic protein-1 (MCP-1), but also acts synergistically in combination with MAPK/ERK inhibitor U0126 and PI3K/Akt inhibitor LY294002. | Chlorpyrifos | tumor necrosis factor | Homo sapiens |
| 3 | Furthermore, CPS-F prevents the PDGF receptor beta (PDGFRbeta) promoter activity induced by PDGF-BB in transfected cells and ameliorates increased levels of TNF-alpha, TNFR1, and MCP-1 when PDGFRbeta is silenced, thereby suggesting that CPS-F possesses a bidirectional regulatory function. | Chlorpyrifos | tumor necrosis factor | Homo sapiens |