Title : Lysosomal ceramide generated by acid sphingomyelinase triggers cytosolic cathepsin B-mediated degradation of X-linked inhibitor of apoptosis protein in natural killer/T lymphoma cell apoptosis.

Pub. Date : 2015 Apr 9

PMID : 25855965






6 Functional Relationships(s)
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1 We previously reported that IL-2 deprivation induced acid sphingomyelinase-mediated (ASM-mediated) ceramide elevation and apoptosis in an NK/T lymphoma cell line KHYG-1. Ceramides H19 imprinted maternally expressed transcript Homo sapiens
2 However, IL-2 deprivation induced ceramide elevation via ASM in lysosomes and activated lysosomal cathepsin B (CTSB) but not cathepsin D. Ceramides H19 imprinted maternally expressed transcript Homo sapiens
3 Inhibition of ceramide accumulation in lysosomes using an ASM inhibitor, desipramine, decreased cytosolic activation of CTSB by inhibiting its transfer into cytosol from the lysosome. Ceramides H19 imprinted maternally expressed transcript Homo sapiens
4 These findings suggest that lysosomal ceramide produced by ASM mediates XIAP degradation by activation of cytosolic CTSB and caspase-dependent apoptosis. Ceramides H19 imprinted maternally expressed transcript Homo sapiens
5 The ASM-ceramide-CTSB signaling axis is a novel pathway of ceramide-mediated apoptosis in IL-2-deprived NK/T lymphoma cells. Ceramides H19 imprinted maternally expressed transcript Homo sapiens
6 The ASM-ceramide-CTSB signaling axis is a novel pathway of ceramide-mediated apoptosis in IL-2-deprived NK/T lymphoma cells. Ceramides H19 imprinted maternally expressed transcript Homo sapiens