Title : A synthetic cGMP-sensitive gene switch providing Viagra(®)-controlled gene expression in mammalian cells and mice.

Pub. Date : 2015 May

PMID : 25843350






1 Functional Relationships(s)
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1 Small-molecule drugs that induce high cGMP levels in specialized tissues by boosting GC activity or inhibiting PDE activity have become the predominant treatment strategy for a wide range of medical conditions, including congestive heart failure, pulmonary hypertension, atherosclerosis-based claudication and erectile dysfunction. Cyclic GMP aldehyde dehydrogenase 7 family member A1 Homo sapiens