Title : Hydroxycarboxylic acid receptors are essential for breast cancer cells to control their lipid/fatty acid metabolism.

Pub. Date : 2015 Aug 14

PMID : 25839160






1 Functional Relationships(s)
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1 The presence of etomoxir or perhexiline, both inhibitors of fatty acid beta-oxidation rescues breast cancer cells with knocked-down HCA3 from cell death.Our data encourages the development of drugs acting on cancer-specific metabolite-sensing GPCRs as novel anti-proliferative agents for cancer therapy. etomoxir hydroxycarboxylic acid receptor 3 Homo sapiens