Pub. Date : 2015 Apr 1
PMID : 25833830
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Loss of TGFbeta Receptor Type 2 Expression Impairs Estrogen Response and Confers Tamoxifen Resistance. | Tamoxifen | transforming growth factor beta 1 | Homo sapiens |
| 2 | Endocrine response involves crosstalk between ERalpha and TGFbeta signaling, such that tamoxifen nonresponsiveness or resistance in breast cancer might involve aberrant TGFbeta signaling. | Tamoxifen | transforming growth factor beta 1 | Homo sapiens |
| 3 | Endocrine response involves crosstalk between ERalpha and TGFbeta signaling, such that tamoxifen nonresponsiveness or resistance in breast cancer might involve aberrant TGFbeta signaling. | Tamoxifen | transforming growth factor beta 1 | Homo sapiens |
| 4 | Functional investigations confirmed that cell cycle or apoptosis responses to estrogen or tamoxifen in ERalpha-positive breast cancer cells were impaired by TGFBR2 silencing, as was ERalpha phosphorylation, tamoxifen-induced transcriptional activation of TGFbeta, and upregulation of the multidrug resistance protein ABCG2. | Tamoxifen | transforming growth factor beta 1 | Homo sapiens |
| 5 | Functional investigations confirmed that cell cycle or apoptosis responses to estrogen or tamoxifen in ERalpha-positive breast cancer cells were impaired by TGFBR2 silencing, as was ERalpha phosphorylation, tamoxifen-induced transcriptional activation of TGFbeta, and upregulation of the multidrug resistance protein ABCG2. | Tamoxifen | transforming growth factor beta 1 | Homo sapiens |