Title : Ligand-induced conformational changes of citrate synthase studied with the fluorescent probe 8-anilinonaphthalene 1-sulfonate.

Pub. Date : 1989 Nov 6

PMID : 2583190






4 Functional Relationships(s)
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1 Ligand-induced conformational changes of citrate synthase studied with the fluorescent probe 8-anilinonaphthalene 1-sulfonate. 8-anilino-1-naphthalenesulfonic acid citrate synthase Homo sapiens
2 Experiments are presented which show that oxaloacetate and analogs thereof with (R)-malate substructure, on interaction with citrate synthase linked to synthase 8-anilinonaphthalene 1-sulfonate (ANS), induce identical conformational changes of a characteristic magnitude. 8-anilino-1-naphthalenesulfonic acid citrate synthase Homo sapiens
3 Experiments are presented which show that oxaloacetate and analogs thereof with (R)-malate substructure, on interaction with citrate synthase linked to synthase 8-anilinonaphthalene 1-sulfonate (ANS), induce identical conformational changes of a characteristic magnitude. 8-anilino-1-naphthalenesulfonic acid citrate synthase Homo sapiens
4 A conformational change of lower magnitude is also produced on binding of CoASH or ATP to citrate synthase.ANS and is completed on addition of oxaloacetate. 8-anilino-1-naphthalenesulfonic acid citrate synthase Homo sapiens