Pub. Date : 2015
PMID : 25825956
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Recent evidence suggests that activation of the innate immune system in the course of obesity is mediated by metabolic signals, such as free fatty acids (FFAs), being elevated in many obese subjects, through activation of pattern recognition receptors thereby leading to stimulation of critical inflammatory signaling cascades, like IkappaBalpha kinase/nuclear factor-kappaB (IKK/NF- kappaB), endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) and NOD-like receptor P3 (NLRP3) inflammasome pathway, that interfere with insulin signaling. | Fatty Acids, Nonesterified | NLR family pyrin domain containing 3 | Homo sapiens |
| 2 | Recent evidence suggests that activation of the innate immune system in the course of obesity is mediated by metabolic signals, such as free fatty acids (FFAs), being elevated in many obese subjects, through activation of pattern recognition receptors thereby leading to stimulation of critical inflammatory signaling cascades, like IkappaBalpha kinase/nuclear factor-kappaB (IKK/NF- kappaB), endoplasmic reticulum (ER) stress-induced unfolded protein response (UPR) and NOD-like receptor P3 (NLRP3) inflammasome pathway, that interfere with insulin signaling. | Fatty Acids, Nonesterified | NLR family pyrin domain containing 3 | Homo sapiens |