Title : Low-pH-induced apoptosis: role of endoplasmic reticulum stress-induced calcium permeability and mitochondria-dependent signaling.

Pub. Date : 2015 May

PMID : 25823563






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1 These observations collectively strongly suggest that both endoplasmic reticulum stress-mediated calcium release and Bax targeting might be altering mitochondrion membrane potential which in turn could induce secondary apoptotic signals; subsequently, endoplasmic reticulum stress can also lead to nuclear localization of Nuclear factor-kappaB (NF-kappaB) which in turn favors p53 mediated apoptotic signals. Calcium tumor protein p53 Homo sapiens