Title : PHY906(KD018), an adjuvant based on a 1800-year-old Chinese medicine, enhanced the anti-tumor activity of Sorafenib by changing the tumor microenvironment.

Pub. Date : 2015 Mar 30

PMID : 25819872






1 Functional Relationships(s)
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1 PHY906 may potentiate Sorafenib action by increasing hMCP1 expression and enhancing infiltration of macrophages into tumors with a higher M1/M2 (tumor rejection) signature expression pattern, as well as affect autophagy by increasing AMPKalpha-P and ULK1-S555-P of tumors. Sorafenib C-C motif chemokine ligand 2 Homo sapiens