Title : Multi-target tacrine-coumarin hybrids: cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease.

Pub. Date : 2015 May 5

PMID : 25812965






1 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Among these compounds, 14c exhibited strong inhibitory activity for AChE (IC50 values of 33.63 nM for eeAChE and 16.11 nM for hAChE) and BuChE (IC50 values of 80.72 nM for eqBuChE and 112.72 nM for hBuChE), and the highest inhibitory activity against hMAO-B (IC50 value of 0.24 muM). Carbon-14 monoamine oxidase B Homo sapiens